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Extra info for ASME Bio Process Equipment (BPE) 2005

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2 In-Tank Couplings (See Fig. SD-21) (a) Use of in-tank shaft couplings shall be by end user consent. (b) Use of in-tank couplings shall be restricted to locations above the liquid level. (c) In-tank couplings shall be of an acceptable hygienic design (see Fig. SD-21). (d) O-rings rather than flat gaskets should be used, if possible. 1 General (a) Agitators and mixers with their associated components shall be accessible to the cleaning fluids as specified by the end user. (b) For cleaning purposes the annular space shall have the target value of L/A ratio of 2:1 or a minimum of 1 in.

B) Flanges are not recommended, and their use shall be minimized. The bore of weld neck flanges shall be the same as the ID of the connected pipe or tubing to prevent ledges and nondrainable areas. (c) Where it is inevitable and class 150 slip-on flanges are used, the bore side bevel weld should be designed in a way to eliminate potential CIP difficulties. (d) During handling and transportation, vessels and their parts and piping assemblies shall be suitably protected to prevent damage to polished surfaces.

19 Plate and frame type heat exchangers should be used only by agreement between owner and designer due to the difficulty of CIP and SIP. 1 General (a) Liquid filled elements in measuring devices should not contain materials that are harmful to the product. (b) Gage siphons (pigtails) should not be used. The number of isolation valves should be minimized. ). (d) Measurement elements should be designed in a way that a failure will not cause contamination hazards to the process and environment. (e) The internal volume of the instrument’s sensing element should be minimized.

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