By J. Folch-Pi (auth.), Rodolfo Paoletti, Alan N. Davison (eds.)
J. Folch-Pi Director of medical learn, McLean sanatorium, Belmont, Mass., U.S.A. the improvement of the vital apprehensive process is potentially the main major element of the expansion of a mammal from embryo to maturity. The significant frightened method is clearly the most repository not just of the species' inherited sensible features but in addition of the method of individuation. no matter what "engrams" represent the foundation of person features are laid down in most cases within the valuable fearful process, and particularly the mind, in the course of its development. The chemical element of this method is obviously of significant value and the importance of its research could be self obvious. however, it is just one element of a parel lei sequence of morphological, physiological, biochemical and mental occasions which occur as an built-in technique, the ultimate results of that's the transformation of the post-embryonic anxious procedure into the functioning grownup process. it really is central, as a result, that any learn or description of the chemical occasions through the improvement of the CNS might be undertaken in ful I information of the concomitant morphological, physiological and mental occasions. it is just by contrast multidiscipl inary informational framework that the chemical occasions in the course of 2 J. FOLCH-PI improvement could be safely interpreted and obtain their ful I importance. With this in brain, the creation to this quantity may well top serve its objective through describing in short the morphological and physiological occasions that accompany the chemical point of development.
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Additional resources for Chemistry and Brain Development: Proceedings of the Advanced Study Institute on “Chemistry of Brain Development,” held in Milan, Italy, September 9–19, 1970
Desmosterol has been found to be present in low concentrations in human brain tumors, such as gl ioblastomas (17). After a short triparanol treatment, desmosterol accumulates in brain tumors but not in the normal surrounding brain. A consequence of this is the possible appearance of desmosterol in cerebrospinal fluid (eSF) of brain tumor bearing patients only. In fact, a correlation exists between the eSF concentration of desmosterol and the 60 R. FUMAGALLI TABLE 2. AVERAGE CSF CONCENTRATIONS OF CHOLESTEROL AND DESMOSTEROL IN PATIENTS TREATED WITH TRIPARANOL PATI ENTS No.
When the total dose varied from 2 to 8 mg/animal the proportion of desmosterol or 7-dehydrocholesterol did not greatly change. This proportion is then the maximum amount replaceable at this age and it may be deduced that the blockade of the corresponding enzymes is maximal at such doses of the drugs. At the end of treatment, more desmostero l i s accumulated than 7-dehydrocholesterol. The levels of both precursors subsequently increase up to 50-60% of total sterols at 30 days of age; 7-dehydrocholesterol is almost completely replaced at 60 days whi Ie some desmosterol is sti I I retained, especially in myel in.
AI though desmostero I I eve I s of the soluble, mitochondrial and nuclear fractions are approximately the same as in the whole brain homogenates, myel in of both brain and spinal cord usually contains much less. Brain desmosterol concentrations decrease considerably during the period between 12 and 20 days of age and the decrease is paral lei in homogenate and myel in. However, desmosterol appears to be retained longer in the myel in fraction (12). 20,25-Diazacholesterol and AY-9944 administered separately to rats (2-d mg/animal by stomach intubation between the 15th and 20th day of life) accumulate desmosterol and 7-dehydrocholesterol respectively in brain and spinal cord myel in (13).