Content material:
Chapter I creation to the Purines (pages 1–30):
Chapter II Syntheses from Pyrimidines (pages 31–90):
Chapter III Purine Syntheses from Imidazoles and different Precursors (pages 91–115):
Chapter IV Purine and the C?Alkyl and C?Aryl Derivatives (pages 117–134):
Chapter V Halogenopurines (pages 135–201):
Chapter VI The Oxo?(Hydroxy?) and Alkoxypurines (pages 203–267):
Chapter VII Thiopurines and Derivatives (pages 269–307):
Chapter VIII The Amino (and Amino?Oxo) Purines (pages 309–365):
Chapter IX The Purine Carboxylic Acids and similar Derivatives (pages 367–399):
Chapter X Nitro?, Nitroso?, and Arylazopurines (pages 401–408):
Chapter XI Purine?N?Oxides (pages 409–426):
Chapter XII The lowered Purines (pages 427–437):
Chapter XIII The Spectra of Purines (pages 439–528):

Show description

Read or Download Chemistry of Heterocyclic Compounds: Fused Pyrimidines, Part II: Purines, Volume 24 PDF

Best chemistry books

LSD-25 & Tryptamine Syntheses Overview & Reference

LSD-25 & Tryptamine Syntheses evaluation & Reference is the main complete reference advisor at the syntheses of LSD-25. Reactions are defined together with a assessment of the duty strength document: Narcotics and Drug Abuse, Annotations and Consultants' Papers. the various reactions contain: Synthesis of N,N-dialkyl substututed lysergamides.

Electronic and Magnetic Properties of Chiral Molecules and Supramolecular Architectures

Time-Dependent Density sensible reaction concept for digital Chiroptical homes of Chiral Molecules, through Jochen Autschbach, Lucia Nitsch–Velasquez, and Mark Rudolph; fresh Theoretical and Experimental Advances within the digital round Dichroisms of Planar Chiral Cyclophanes, via Yoshihisa Inoue and Tadashi Mori; G-C content material autonomous Long-Range cost move via DNA, via Kiyohiko Kawai and Tetsuro Majima; move of Chirality for reminiscence and Separation, by way of Rosaria Lauceri, Alessandro D’Urso, Angela Mammana and Roberto Purrello; Vibrational round Dichroism Spectroscopy four of Chiral Molecules, by way of Guochun Yang and Yunjie Xu; Spin Selective Electron Transmission via Monolayers of Chiral Molecules, by means of Ron Naaman and Zeev Vager; Chiral keep an eye on of present move in Molecules, via Vered Ben-Moshe, David N.

Computational Studies in Organometallic Chemistry

The sequence constitution and Bonding publishes serious experiences on issues of analysis occupied with chemical constitution and bonding. The scope of the sequence spans the complete Periodic desk and addresses constitution and bonding matters linked to all the components. It additionally focuses recognition on new and constructing components of recent structural and theoretical chemistry equivalent to nanostructures, molecular electronics, designed molecular solids, surfaces, steel clusters and supramolecular buildings.

Additional info for Chemistry of Heterocyclic Compounds: Fused Pyrimidines, Part II: Purines, Volume 24

Example text

16 Chapter I e. Thio- (and Methylthio-) to Oxopurines (Ch. VI, Sect. IF) As in related heterocyclic systems, such as pyrimidines, thio groups in purines show reIuctance toward hydrolytic conversion to the 0x0 form. , nitric and nitrous acids) for this purpose are to be found but this approach has IittIe practical application as more productive procedures are available. Of the methods outlined below the first two have general application and the others a more limited scope. (a)Mild oxidising agents convert a thio group to the sulphinic or higher oxidised sulphonic acid form.

If akylation with chloroaceticacid, rather than an alkyl halide, is made the carboxymethylthiopurine produced can be very acid labile. (d) Miscellaneous strong oxidising agents, which include hydrogen peroxide, manganese dioxide, and nitric acid have been used to replace the sulphur atom by oxygen, but the likelihood that the sulphydryl group may be replaced by hydrogen under these conditions is aIways present. Scheme B (R = purinyl) summarises these conversions. RSOaH f t 1 RSH + RSCHoCOzH RSMe SCHEMEB ----f P RSOzOH ROH 1 RS0,Me f.

2). The analogous oxazolo[5,4-d]pyrimidines,from 6-oxopyrimidines, are not formed under the usual cyclising conditions but their isolation after the use of vigorous, strongly acid conditions has been made. If in addition interesting to note that the first example of pteridine formation arose from4 an attempted purine preparation. However, not all I ,2-dicarbonyl derivatives give pteridines, as examples exist in which only one of the carbonyl groups takes part in the reaction, and a purine is formed.

Download PDF sample

Rated 4.88 of 5 – based on 36 votes