By Franz Halberg (auth.), Lawrence E. Scheving Ph.D., Franz Halberg M.D., Charles F. Ehret Ph.D. (eds.)
High blood strain (BP) (with fat and smoking) is among the 3 roots of cardio-cerebro-renovascular disorder affecting as much as 25% of the grownup inhabitants. accordingly, hypertension may be well-known and taken care of, to minimize any issues and delay existence, as famous by means of Michael Weber of the Veterans management clinic in lengthy seashore, California. He additional emphasizes the necessity for tracking sooner than one begins the remedy of hypertension. certainly, he refers back to the result of the Australian learn on gentle high blood pressure with a wide percent of placebo responders and rightly means that many folks are taken care of who shouldn't be as a result of 'white-coat-associated excessive blood pressure'. He additionally issues to the shortcoming of standardization of strategies for facts research and of equipment of BP dimension. Ambulatory tracking less than traditional condi tions with no concomitant recording of occasions doesn't permit even a qualitative overview of the effect of various stimuli, in weber's opinion.
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Realized that these anal yses deal with onl y a si ogle frequency, the ci rcadian, and ignore even the ci rcadian waveform, as well as ultradians and i nfradians. For qualification, see text. , in press. V~ Ectopic . . (VElla) In PatIenIa - . I8cIWnIc _ IliMaM Who Survived (---t or DIed ~ wIIhIn 5 Y. . 01 24-ttoor ECO RecordIng fig~ - ----_ ... ,. dl . . , d ... d 0' aliv. wll""" 80 continued from page 14 tumor every 2 hours for several days, the average time of peal: tumor temperature "lias determined in each case.
The single dose, lD50/30 (obtained in 1958 in the Chronobiology laboratories, University of Minnesota), varies by nearly 100 r as a function of ci rcedian ti mi 09. ©1960 by Halberg. fig~ (below): Timing complements dosi ng for gai n in treati ng cancer. Tumor regression is of about 70% on the average when treatment is given at pe8~ tumor temperature, whereas it may onl y be of about 30% on the average with treatment at other ti mes (left) . Agai n of 2 from treatment at pea~ tumor temperature as mar~er rhythm is shown on the right.
III. t via the drug pump A Medtronic implantable and externally programmable pump (figure 13a,b) was used on 21 outbred beagle dogs to admi nister cyclospori ne with one of seve nIl ci rcadian 5i nusoida1 schedules or at a constant rate. The dogs were kept in 12 h of light alternati ng with 12 h of darkness. , in press a). fig. 14e presents results on 9 dogs. When they are untreated, they live 5- 7 days. This averaQe of about 6 days can be improved by treatment with cyc10spori ne, as shown in fig.